Fig. 2.

In vivo efficacy of CT-P59 against Delta variant in mice. Negative control (NC) indicates naïve mice without virus infection. Vehicle and 5, 20, 40 and 80 mg/kg of CT-P59 were administered intraperitoneally 8 h after virus inoculation. Body weights and survival rates were monitored daily (A, B). The weight per mouse on day 0 was used as a baseline, and weight change was determined relative to baseline. 25% or higher of weight loss was considered to be dead. Five and four animals each were euthanized for virus titration at 3 dpi and 6 dpi, respectively. The virus titers from lung tissue was measured (C, D) using plaque assay. Alphabets and asterisks indicates statistical significance between the virus only and each treatment group as determined by one-way ANOVA followed by a Dunnett's post-hoc test. a denotes statistically significant difference (p < 0.05) between virus only and each treatment group (5, 20, 40 and 80 mg/kg). b denotes statistically significant difference (p < 0.05) between virus only and 40 mg/kg c denotes statistically significant difference (p < 0.05) between virus only and each treatment group (40 and 80 mg/kg). ∗∗∗ indicates P < 0.001, and ∗∗∗∗ indicates P < 0.0001 between virus only and each treatment group.