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. 2021 Sep 11;21:1017. doi: 10.1186/s12885-021-08751-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Estrogen reduces circulating neutrophil in tumour-bearing mice. Experiment is conducted according to the description in Fig. 1. A, Tumour burden increases circulating neutrophils which were reduced with estrogen treatment in both Inv and Null mice; Percentage of circulating neutrophils (CD45⁺CD11b⁺Ly6G⁺) out of viable CD45⁺ population via flow cytometry analysis, Null+Ctrl (no tumour - N.T) n = 3, Null+Ctrl n = 8, Null+E2V n = 8, Inv + Ctrl (N.T) n = 6, Inv + Ctrl n = 12, Inv + E2V n = 13. B, Number of neutrophils per ml of blood, Null+Ctrl (N.T) n = 3, Null+Ctrl n = 5, Null+E2V n = 5, Inv + Ctrl n = 5, Inv + E2V n = 6. C, Estrogen-induced reduction of circulating neutrophils in tumour-bearing mice were not due to increase in other circulating leukocytes; (i) Percentage of circulating monocytes (CD45⁺CD11b⁺Ly6C^hi) out of viable CD45⁺ population, (ii) Percentage of circulating CD4 T-cells (CD45⁺CD4⁺CD8⁻) out of viable CD45⁺ population, (iii) Percentage of circulating CD8 T-cells (CD45⁺CD8⁺CD4⁻) out of viable CD45⁺ population via flow cytometry analysis, Null+Ctrl (N.T) n = 3, Null+Ctrl n = 8, Null+E2V n = 8, Inv + Ctrl (N.T) n = 6, Inv + Ctrl n = 12, Inv + E2V n = 13. Data represented as mean ± SEM. Statistical significances determined using one-way ANOVA followed by post-hoc tukey test