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. 2021 Sep 12;20:104. doi: 10.1186/s12944-021-01539-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Kaplan–Meier survival analysis after applying a combination of prognostic factors. The stage (low: I + II vs. high: III + IV), age (low: < 70 vs. high: ≥ 70), and NPC1L1 (low expression vs. high expression) groups were each divided into two groups. Then, survival analysis was performed by combining prognostic factors. The red line indicates a high stage and/or high NPC1L1 expression and/or older age group. The blue line indicates a low stage and/or low NPC1L1 expression and/or younger age group. The green line indicates mixed combination groups, excluding all high and all low combination groups. a Stage-only group. b NPC1L1 and stage group. c Stage and age group. d NPC1L1, stage, and age group