Table 2.

Endocrinopathies and mechanism for causing hypertriglyceridemia

Disorder	Mechanism
Hypothyroidism [16]	Decreased clearance via HL/LPL [17] Increased AngPTL3 expression [18] Note: not observed in subclinical disease [19, 20]
Cushing’s syndrome [21]	Insulin resistance, changes in FFA metabolism and adipocyte function, typically accompanied by diabetes and obesity [22]
Acromegaly [23]	Growth hormone (GH) direct inhibitory inhibits HL/LPL accompanied by insulin resistance and metabolic diseases [24, 25]
Male hypogonadism [26]	Unclear, possible confounding by comorbid and correlated obesity and metabolic syndrome [27, 28]
Hyperprolactinemia [29]	Proposed mechanisms include hypothalamic-pituitary–gonadal axis disruption, weight changes and subsequent insulin resistance, or possibly direct LPL effects [30–32]
Polycystic ovary syndrome [33]	Insulin resistance, hyperandrogenism, often exacerbated by obesity and/or diabetes [34]

List of endocrinopathies that contributes to hypertriglyceridemia and proposed mechanisms