TABLE 3.
International mouse phenotyping consortium Kdelr2 LOF phenotypes
| Phenotype | Zygosity | Life stage | p‐value |
| Abnormal embryo size | htz, hmz | E9.5, E18.5 | 0.00 |
| Abnormal head size | hmz | E18.5 | 0.00 |
| Abnormal heart looping | htz | E.9.5 | 0.00 |
| Increased exploratory behavior | htz | early adult | 1.17 × 10−7 |
| Abnormal bone mineralization | htz | early adult | 1.39 × 10−6 |
| Abnormal facial morphology | hmz | E18.5 | 0.00 |
| Preweaning lethality, incomplete penetrance | hmz | early adult | 0.00 |
| Abnormal head shape | hmz | E18.5 | 0.00 |
| Abnormal bone structure | htz | early adult | 1.75 × 10−7 |
| Abnormal body wall morphology | hmz | E18.5 | 0.00 |
Abbreviations: hmz, homozygous; htz, heterozygous.