FIGURE 5.

Regulation of circulating and brain tissue glycine by benzoate and cinnamate. A, Oral administration of benzoate or cinnamate significantly lowers plasma glycine concentration in adult Gldc ^GT1/GT1 wild‐mice but not in wild‐type mice. B‐F, Glycine and glycine derivatives accumulate in brain of adult Gldc ^GT1/GT1 mice, with normalisation following benzoate or cinnamate treatment. G, In contrast, while hippurate is detectable in brain of untreated mice, its abundance is significantly increased following benzoate or cinnamate treatment (^#significantly different from wild‐type, * significantly different from untreated Gldc ^GT1/GT1, P < .05; ANOVA, n = 4‐5 per group)