TABLE 5.

Effect of Oxygen Supplementation at Baseline With Timing of Remdesivir Therapy on Progression to Mechanical Ventilation

Oxygen Supplementation at Baseline	Timing of RDV From First Positive PCR Test	Total n	Progression to Mechanical Ventilation (%)	P = 0.004
None	≤3 d	20	10
	>4 d	4	50
Low flow*	≤3 d	179	8
	>4 d	16	31
High flow†	≤3 d	150	23
	>4 d	44	68
Mechanical ventilation	≤3 d	14	100
	>4 d	29	100

Missing data—4.6% for oxygen supplementation.

*Via nasal cannula.

^†High-flow nasal cannula, continuous positive airway pressure, bilevel positive airway pressure.

RDV indicates remdesivir.