Comparison 2. Auranofin vs. placebo ‐ Withdrawals and dropouts.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Withdrawals: Global reasons	9		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only
1.1 Withdrawals: total	9	1049	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.62 [0.46, 0.83]
1.2 Withdrawals: lack of effect	9	1049	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.31 [0.21, 0.44]
1.3 Withdrawals: concurrent illness	9	1049	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.74 [0.86, 8.69]
1.4 Withdrawals: adverse reactions	9	1049	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.52 [0.94, 2.46]
2 Withdrawals: System specific adverse reactions	9		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only
2.1 Withdrawals: gastrointestinal ‐all signs and symptoms	9	1049	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.98 [1.36, 6.52]
2.2 Withdrawals: diarrhea	9	1049	Peto Odds Ratio (Peto, Fixed, 95% CI)	3.02 [1.29, 7.06]
2.3 Withdrawals: mucosal / cutaneous adverse reactions	9	1049	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.56 [0.75, 3.23]
2.4 Withdrawals: renal adverse reactions	9	1049	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.96 [0.53, 7.27]
2.5 Withdrawals: liver adverse reactions	0	0	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.0 [0.0, 0.0]
2.6 Withdrawals: hematology adverse reactions	9	1049	Peto Odds Ratio (Peto, Fixed, 95% CI)	3.73 [0.84, 16.65]
2.7 Withdrawals: neurological adverse reactions (headache, dizziness, tingling)	9	1049	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.52 [0.10, 2.59]
2.8 Withdrawals: cardiovascular adverse reactions	8	984	Peto Odds Ratio (Peto, Fixed, 95% CI)	7.16 [0.14, 360.90]
2.9 Withdrawals: miscellaneous adverse reactions	9	1049	Peto Odds Ratio (Peto, Fixed, 95% CI)	7.20 [0.45, 115.73]