Comparison 3. Adverse reactions not requiring withdrawal.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Adverse reactions: System specific	6		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only
1.1 Adverse reaction: gastrointestinal	5	595	Peto Odds Ratio (Peto, Fixed, 95% CI)	3.11 [2.09, 4.65]
1.2 Adverse reaction: diarrhea	5	595	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.95 [1.95, 4.47]
1.3 Adverse reaction: mucosal / cutaneous	4	291	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.08 [1.13, 3.81]
1.4 Adverse reaction: renal	5	293	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.97 [0.23, 4.03]
1.5 Adverse reaction: liver	4	291	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.0 [0.0, 0.0]
1.6 Adverse reaction: hematology	4	291	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.0 [0.0, 0.0]
1.7 Adverse reaction: neurological	4	291	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.0 [0.0, 0.0]
1.8 Adverse reaction: miscellaneous	4	291	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.61 [0.83, 3.13]