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Inhibition of NF-κB partially reversed the si-NLRC5-mediated promotion of IL-1β-induced inflammatory injury in chondrocytes. Chondrocytes were treated with PDTC (5 ;μM) to prevent the activation of NF-κB signaling pathway. (A) Cell viability of chondrocytes was detected using MTT assay. (B, C) The mRNA levels of iNOS and COX-2 were measured using RT-PCR. (D–G) The production of TNF-α, IL-6, MMP-3/13 in chondrocytes. *p < 0.05.
