Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Aug 24;13(16):20629–20650. doi: 10.18632/aging.203452

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © 2021 Gong et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PMC Copyright notice

Integrated cross-species analysis between human and mouse osteoblasts in vivo. (A) UMAP visualization of human and mouse osteoblast integration. The upper-left plot represents the three osteoblast clusters in mice, the upper-right plot indicates the three osteoblast subtypes in humans. The bottom plot represents the five clusters after the integration, colored by clusters. The middle-right is the integrated data colored by different species. (B) Correlation of gene expression among different osteoblast datasets after CCA integration. Each dot represents an individual gene. Axes measure the average gene expression levels (logFC) in the indicated subject. Correlations were measured by Spearman correlation coefficients (R) (p < 0.01). (C) Log-normalized expression of NR4A1 in human and mouse integrated data. (D) Proportion of the human and mouse osteoblasts in each cluster after CCA integration, colored by different species. The x-axis represents five different clusters and y-axis indicates the proportion.