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. 2021 Aug 18;13(16):20372–20382. doi: 10.18632/aging.203417

Figure 6.

Figure 6

CircRHOT1/c-MYC signaling contributes NSCLC cell proliferation in vitro and in vivo. (A and B) The A549 and H1299 cells were treated with circRHOT1 siRNA or co-treated with circRHOT1 siRNA and KAT5 overexpression vector or c-MYC overexpression vector. The cell survival was detected by Edu assays. (C–F) The nude mice (n = 5) were injected with A549 cells treated with circRHOT1 siRNA or co-treated with circRHOT1 siRNA and c-MYC overexpression vector. The tumor image (C), tumor weight (D), and tumor volume (E) were shown. (F) The Ki-67 levels were analyzed by IHC staining. mean ± SD, **P < 0.01.