Figure 2.

AirPoll-nPM induces amyloidogenic responses in mouse cerebral cortex after exposure for 8–10 wk of high traffic levels. (A) Amyloidogenic responses of J20 male mice carrying APPswe (familial AD gene) showing increase of soluble Aβ42 and Aβ plaque load (39), and increased lipid raft levels of amyloid precursor protein (APP) (39). *p<.05, **p<0.01 (B) Amyloid metabolic gene response of APOE-TR mice carrying human APOE3 and APOE4 alleles by targeted replacement (no familial AD genes) (49). * p<.05 in ANOVA test after FDR multiple test correction. AirPoll = air pollution; nPM = nanoscale subfraction of particular matter.