Figure 4.

APOE gene cluster expression in mouse and human brain. (A) Heat maps showing transcriptional response of the mouse Apoe gene cluster to AirPoll-nPM in cerebral cortex, for C57BL/6J (B6) and transgenic for human APOE allele, APOE3-TR and APOE4-TR, both sexes. Principal component analysis of human APOE cluster expression for 5 brain regions (321 individuals, GTEx data) shows APOE PC1 differed by sex (B) and age (C) with brain region specificity. Figure adapted from Haghani et al. (60). AirPoll = air pollution; CigS = cigarette smoke.