TABLE 2.
Compound | HTCC1062 intracellular concn (μM) |
HTCC7211 intracellular concn (μM) |
||||
---|---|---|---|---|---|---|
Neg. Control | +Polyamines | P value | Neg. Control | + Polyamines | P value | |
Putrescine | 16 ± 6.7 | 93 ± 23 | 0.003 | 6 ± 0.3 | 4,030 ± 1,860 | 0.03 |
Cadaverine | 0 | 1.5 ± 1 | 0.03 | 0 | 153 ± 31 | 0.0002 |
Agmatine | 0 | 3 ± 2.1 | 0.03 | 0 | 1,460 ± 940 | 0.02 |
Nor-spermidine | 0 | 3.8 ± 1.6 | 0.01 | 0 | 1,020 ± 490 | 0.003 |
Spermidine | 328 ± 127 | 480 ± 130 | 0.19 | 12 ± 2.7 | 19,100 ± 9,630 | 0.01 |
Concentrations were calculated using cell volumes of 0.03 and 0.04 μm3 for HTCC1062 and HTCC7211, respectively. The listed P values are for a one-sided t test comparing the +polyamine treatment to the negative-control treatment.