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. Author manuscript; available in PMC: 2022 Aug 31.
Published in final edited form as: Circulation. 2021 Aug 30;144(9):680–683. doi: 10.1161/CIRCULATIONAHA.121.056140

Figure : Pleiotropic effects of statins.

Figure :

Plus sign = enhanced/activated; minus sign = inhibited; AT11 = angiotensin 1; ET-1 = endothelin 1; hs-CRP = high-sensitivity C-reactive protein; MMPs = matrix metalloproteinases; NO = nitric oxide; PAI-1 = plasminogen activator inhibitor-1; ROS = reactive oxygen species; SMC = smooth muscle cell; TF = tissue factor; t-PA = tissue-type plasminogen activator; TXA2 = thromboxane A2. (Reprinted with permission5)