Skip to main content
. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Hypertension. 2021 Jul 7;78(2):252–260. doi: 10.1161/HYPERTENSIONAHA.121.16495

Figure 1: Sodium (Na+) sensing and activation of NADPH oxidase by antigen presenting cells.

Figure 1:

Na+ enters antigen presenting cells through the epithelial Na+ channel (ENaC) leading to intracellular Ca2+ influx via the Na+/Ca2+ exchanger (NCX) and activation of PKC. PKC phosphorylates p47phox leading to assembly of NADPH oxidase and increased production of reactive oxygen species (ROS).