Table 3.

Conditional effect of HSD17B13 rs72613567 (−/A) + (A/A) genotypes on risk of steatohepatitis and fibrosis at levels of moderators

Moderators	Univariate analysis				Multivariable analysisb
	Conditional effecta	Standard error	95% CI	P value	Conditional effecta	Standard error	95% CI	P value
Steatohepatitis categories (0–2)
PNPLA3 rs738409
CC, n = 377	−0.21	0.08	−0.37 to −0.04	0.014	−0.19	0.08	−0.35 to −0.03	0.019
GC + GG, n = 776	−0.09	0.06	−0.21 to 0.03	0.136	−0.08	0.05	−0.19 to 0.03	0.150
BMI ≥35, n = 506	−0.18	0.06	−0.29 to −0.06	<0.01	−0.17	0.06	−0.28 to −0.06	<0.01
BMI <35, n = 647	−0.03	0.09	−0.20 to 0.15	0.766	−0.003	0.09	−0.17 to 0.17	0.972
Age ≥45, n = 838	−0.18	0.06	−0.30 to −0.07	<0.01	−0.18	0.06	−0.29 to −0.07	<0.01
Age <45, n = 315	0.02	0.09	−0.16 to 0.20	0.845	0.02	0.09	−0.16 to 0.19	0.851
Women, n = 727	−0.18	0.06	−0.30 to −0.06	<0.01	−0.18	0.06	−0.29 to −0.06	<0.01
Men, n = 426	−0.04	0.08	−0.19 to 0.12	0.661	−0.03	0.08	−0.18 to −013	0.751
T2D (yes), n = 408	−0.18	0.08	−0.34 to −0.02	0.026	−0.18	0.08	−0.34 to −0.03	0.022
T2D (no), n = 745	−0.09	0.06	−0.21 to 0.03	0.130	−008	0.06	−0.20 to 0.03	0.145
Fibrosis (0–4)
PNPLA3 rs738409
CC, n = 377	−0.50	0.13	−0.77 to −0.23	<0.001	−0.45	0.12	−0.70 to −0.20	<0.001
GC + GG, n = 776	−0.03	0.09	−0.22 to 0.16	0.735	−0.008	0.09	−0.18 to 0.17	0.932
BMI ≥35, n = 506	−0.28	0.09	−0.46 to −0.09	<0.01	−0.22	0.08	−0.40 to −0.05	0.010
BMI <35, n = 647	−0.01	0.14	−0.30 to 0.27	0.921	0.002	0.13	−0.26 to 0.27	0.991
Age ≥45, n = 838	−0.24	0.09	−0.42 to −0.06	0.010	−0.23	0.09	−0.40 to −0.06	<0.01
Age <45, n = 315	−0.05	0.14	−0.34 to 0.23	0.711	−0.04	0.14	−0.31 to 0.24	0.799
Women, n = 727	−0.19	0.09	−0.39 to 0.00	0.051	−0.17	0.09	−0.35 to 0.01	0.067
Men, n = 426	−0.18	0.12	−0.43 to 0.07	0.162	−0.14	0.12	−0.37 to 0.10	0.262
T2D (yes), n = 408	−0.33	0.12	−0.58 to −0.08	0.010	−0.32	0.12	−0.56 to −0.07	0.011
T2D (no), n = 745	−0.10	0.09	−0.28 to 0.09	0.291	−0.07	0.09	−0.2 to 0.11	0.429

The reference genotype for all comparative analyses HSD17B13 rs72613567 (−/−).

BMI, body mass index; CI, confidence interval; T2D, type 2 diabetes.

^aRepresents the effect of the exposure (HSD17B13 rs72613567 (−/A) + (A/A) genotypes) on outcomes at values of the moderator (i.e., PNPLA3 rs738409 genotypes (CC) or (GC) + (GG)).

^bAnalysis adjusted for nonheavy alcohol intake and those covariates not tested as moderators.