Table 4.

Conditional effect of HSD17B13 rs72613567 (−/A) + (A/A) genotypes on risk of steatohepatitis and fibrosis at levels of 2 moderators (sex and age <51 or ≥ 51 yr)

Moderators	Univariate analysis				Multivariable analysisb
	Conditional effecta	Standard error	95% CI	P value	Conditional effecta	Standard error	95% CI	P value
Steatohepatitis categories (0–2)
Men/<51, n = 238	0.05	0.11	−0.16 to 0.26	0.619	0.06	0.10	−0.15 to 0.26	0.584
Men/≥51, n = 188	−0.15	0.12	−0.39 to 0.08	0.190	−0.11	0.11	−0.34 to 0.11	0.327
Women/<51, n = 286	−0.03	0.09	−0.21 to 0.16	0.756	−0.02	0.09	−0.20 to 0.16	0.834
Women/≥51, n = 441	−0.28	0.08	−0.44 to −0.12	0.001	−0.31	0.08	−0.46 to −0.15	<0.001
Fibrosis (0–4)
Men/<51, n = 238	−0.09	0.17	−0.43 to 0.24	0.567	−0.08	0.16	−0.40 to 0.24	0.624
Men/≥51, n = 188	−0.31	0.19	−0.68 to 0.06	0.103	−0.22	0.18	−0.57 to 0.14	0.232
Women/<51, n = 286	−0.15	0.15	−0.45 to 0.14	0.317	−0.11	0.14	−0.39 to 0.18	0.459
Women/≥51, n = 441	−0.17	0.13	−0.42 to 0.08	0.196	−0.23	0.12	−0.47 to 0.01	0.062

The reference genotype for all comparative analyses HSD17B13 rs72613567 (−/−). CI, confidence interval.

^aRepresents the effect of the exposure (HSD17B13 rs72613567 (−/A) + (A/A) genotypes) on outcomes at values of moderators.

^bAnalysis adjusted for PNPLA3 rs738409, nonheavy alcohol intake, body mass index, and type 2 diabetes.