Table 4.

Association between past DDT use and epigenetic age acceleration among male farmers of European ancestry in the Agricultural Lung Health Study, 2009–2013.

Epigenetic clock	Alla			At least 18 years of age in 1972b
	$\mathrm{\beta }$	95% CI	$p$-Value	$\mathrm{\beta }$	95% CI	$p$-Value
Horvath	0.44	$-0.39$, 1.26	0.30	0.67	$-0.23$, 1.58	0.14
Hannum	1.15	0.34, 1.96	0.006	1.26	0.36, 2.15	0.005
Skin and blood	0.81	0.07, 1.55	0.03	1.14	0.33, 1.95	0.006
PhenoAge	0.77	$-0.26$, 1.80	0.14	1.08	$-0.05$, 2.22	0.06

Note: Analyses conducted using linear regression, adjusting for the selection factor (asthma status), age at blood collection, pack years, smoking (never, former, current), state of residence, and seven estimated cell types. CI, confidence interval; DDT, dichlorodiphenyltrichloroethane.

^aPast use/never use ($n/n$) was 375/765.

^bPast use/never use ($n/n$) was 365/453.