Figure 2.

Median predicted CVLT trajectory over time by latent class in the WHIMS-ECHO cohort, stratified by age. (A) In women $\le 80\text{\hspace{0.17em}years of age}$, the average rate of change in CVLT scores was $-0.12/\mathrm{y}$ (95% CI: $-0.23$, $-0.01$; $p=0.03$) for the slow-decliner latent class ($n=643$, according to the baseline LCMM) and $-1.79/\mathrm{y}$ (95% CI: $-2.08$, $-1.50$; $p<0.001$) for the fast-decliner class ($n=185$). (B) In women $>80\text{\hspace{0.17em}years of age}$, the average rate of change in CVLT scores was 0.18/y (95% CI: $-0.004$, 0.36; $p=0.06$) for the cognitively resilient latent class ($n=351$, according to the baseline LCMM) and $-1.35/\mathrm{y}$ (95% CI: $-1.53$, $-1.17$; $p<0.001$) for the steady-decliner class ($n=877$). Solid lines indicate the median predicted change in CVLT scores over time for women who were (A) 78 or (B) 84 years of age at WHIMS-ECHO enrollment. The predicted CVLT scores were estimated using baseline LCMMs with age at WHIMS-ECHO enrollment and follow-up time as the only predictors. Shaded regions denote 95% CI. Note: CI, confidence interval; CVLT, California Verbal Learning Test; LCMM, latent class mixed model; WHI-CT (HT), Women’s Health Initiative-Clinical Trial (Hormone Therapy); WHIMS-ECHO, Women’s Health Initiative Memory Study-Epidemiology of Cognitive Health Outcomes.