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. Author manuscript; available in PMC: 2022 Jun 16.
Published in final edited form as: J Am Chem Soc. 2021 Jun 1;143(23):8661–8668. doi: 10.1021/jacs.1c02206

Figure 2.

Figure 2.

A: Representative LC trace collected after 1 (1.2 equiv) and H2N-VKGALGVCG-CONH2 (5 mM) were allowed to react for 1.5 h at 25 °C in the presence of Tris•HCl buffer (30 mM) in dimethylformamide (DMF). Internal standard was produced through alkylation of H2N-VKGALGVCG-CONH2 (see SI section I). B: Proposed reaction scheme between 1 and cysteine-containing peptide C: Peptide substrate scope with isolated yields (%) and conversion (%).