FIG 1.

Prazoles inhibit EBV release from lytically induced cells. CLIX-FZ BL cells were exposed to doxycycline to activate the lytic phase of EBV (Dox) or Dox plus prazoles (T, tenatoprazole; I, ilaprazole; R, rabeprazole). (A) Culture supernatants were harvested 72 h later, treated with DNase, and assayed for EBV load using qPCR. **, P < 0.001. Error bars show standard errors of the means (SEM) for biological triplicates. (B) Cells were harvested at 48 h and surface stained using reference EBV-seronegative control serum (top) or reference EBV-seropositive serum to identify lytically active cells (bottom).