FIG 5.

Prazoles negatively impact capsid maturation and size of extracellular virions. CLIX-FZ BL cells were exposed to doxycycline (Dox) plus prazoles. Cells were harvested 48 h later for evaluation by electron microscopy. (A) Numerous nuclear VLPs. Cartoons next to panel A1 indicate the three morphologies shown in panels A and A1. Normal-appearing and defective VLPs are circled in red and yellow, respectively, in panel A. (B and C) Extracellular virions. Sizes of nuclear capsids and extracellular VLPs are also indicated. (D) Percent empty nuclear capsids in doxycycline versus doxycycline plus prazole-treated cells. **, P < 0.01.