FIG. 2.
Induction of oligonucleosomal DNA fragmentation and processing of caspase-3 by growth factor deprivation and PI 3-kinase inhibition. Rat-1/B-Raf-1 and Rat-1 cells were maintained and treated as described in the legend to Fig. 1. (A) Oligonucleosomal fragmentation of DNA. (B) Immunoblot analysis of caspase-3. The positions of the 32-kDa proenzyme and the 20-kDa active subunit are indicated by arrows.