FIG 5.
LDH-A enhanced Spn pathogenesis. Mice were infected (A) intratracheally with 5.0 × 106 CFU of WU2 or (B) 1.0 × 105 CFU of TIGR4 following coincubation and alongside rabbit LDH-A. (C) Mice were infected intratracheally with Spn preincubated with rabbit LDH-A. Mice received 1.0 × 106 CFU of EF3030, EF3030-04, or EF3030-05 intratracheally. Shown are bacterial titers in the lungs and blood 24 h after challenge. Shapes in panels A, B, and C represent bacterial burden for each mouse. Statistical analyses were performed using a Mann-Whitney U test or Kruskal-Wallis test with two-way ANOVA.