Figure 6.

Deficiency of MGL in the tumor microenvironment (TME) alters the immune cell infiltrate in tumors of a non-small cell lung cancer model

Summary of differences observed in the TME cell landscape of MGL wild type (WT) and MGL knockout (KO) mouse tumors. An increase in levels of 2-AG in tumors from MGL KO mice is accompanied by increased infiltration of eosinophils and CD8⁺ T cells. Furthermore, the number of effector cells (Teff) and the expression of PD-1⁺ on CD8⁺ T cells are increased. The altered TME cell profile in the MGL KO mice may favor tumor reduction. (Tnai= naive T cells).