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Effects of PE on (a) femur bone mineral density (BMD), (b) estradiol (E2), (c) osteocalcin (OC), and (d) estrogen receptor-alpha (ER-α) protein expression. Each column represents the mean ± standard error of mean (SEM). ∗p < 0.05vs. sham group; #p < 0.05, ##p < 0.01, ###p < 0.001, and ####p < 0.0001vs. OVX group.
