Table 3.

Effects of PE on serotonin and bone turnover markers in OVX rats.

	Serotonin (ng/mL)	CTX-1 (pg/mL)	DYP (nmol/L)	PYD (ng/mL)
Sham	200.10 ± 28.19	167.10 ± 14.10	2.10 ± 0.10	27.07 ± 0.97
OVX	390.20 ± 67.26∗	155.5 ± 8.14	3.07 ± 0.18∗∗∗	34.92 ± 3.20∗
PE-25	264.30 ± 38.04	106.80 ± 7.95##	2.37 ± 0.07###	27.47 ± 1.51#
PE-100	205.70 ± 22.92#	110.60 ± 7.14#	2.23 ± 0.12####	25.86 ± 1.42##
PE-400	222.60 ± 40.00#	104.10 ± 11.25##	2.34 ± 0.08###	25.18 ± 1.06###
PE-1600	159.40 ± 45.05##	96.24 ± 9.87###	2.09 ± 0.10####	25.31 ± 0.88##

Data are presented as the mean ± standard error of mean (SEM). Sham, sham operation; OVX, ovariectomy; PE-25, OVX + PE 25 mg/kg; PE-100, OVX + PE 100 mg/kg; PE-400, OVX + PE 400 mg/kg; PE-1600, OVX + PE 1600 mg/kg; CTX-1, C-terminal telopeptide fragment of type I collagen; DYP, deoxypyridinoline; PYD, pyridinoline. ^∗p < 0.05 and ^∗∗∗p < 0.001vs. sham group; ^#p < 0.05, ^##p < 0.01, ^###p < 0.001, and ^###p < 0.0001vs. OVX group.