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. 2021 Sep 4;2021:6673967. doi: 10.1155/2021/6673967

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Copyright © 2021 Hailun Jiang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Tilianin protection of hNCs against OGD depended on inhibition of CaMKIIα. (a) Representative immunofluorescence images of ox-CaMKII positivity. Bar: 100 μm. (b) Mean fluorescence intensity of ox-CaMKII (n = 4). (c) Decreased viability of OGD-injured hNCs treated with tilianin in the presence of CaMKIIα siRNA. (d) Representative images of TUNEL staining. Bar: 100 μm. (e) Increased apoptosis of OGD-injured hNCs treated with tilianin in the presence of CaMKIIα siRNA. (f) Increased caspase-3 activity of OGD-injured hNCs treated with tilianin in the presence of CaMKIIα siRNA. Results represent means ± SD. ^###P < 0.001 vs. control; ^∗∗P < 0.01, ^∗∗∗P < 0.001 vs. OGD; ^@@@P < 0.001 vs. control + NC siRNA; ^&&&P < 0.001 vs. OGD + NC siRNA; ^%%%P < 0.001 vs. control + CAMK2A siRNA; ^$P < 0.05, ^$$P < 0.01 vs. OGD + NC siRNA + tilianin.