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. 2021 Sep 4;2021:6673967. doi: 10.1155/2021/6673967

Figure 12.

Figure 12

Tilianin inhibited CaMKIIα-dependent intrinsic apoptosis and the inflammatory signaling pathway of OGD-injured hNCs but was blocked by the action of CaMKIIα siRNA. (a) Representative immunofluorescence images of Bax, Bcl-2, and p-p65. Bar: 100 μm. (b, c) Mean fluorescence intensity of Bax (b) and Bcl-2 (c) (n = 4). (d) Increased activity of p-p65 of OGD-injured hNCs treated with tilianin after the addition of CaMKIIα siRNA. (e, f) Increased expression of TNF-α (e) and IL-6 (f) in OGD-injured hNCs treated with tilianin after the addition of CaMKIIα siRNA. Results represent means ± SD. @@P < 0.01, @@@P < 0.001 vs. control + NC siRNA; &P < 0.05, &&P < 0.01, &&&P < 0.001 vs. OGD + NC siRNA; $P < 0.05, $$P < 0.01, $$$P < 0.001 vs. OGD + NC siRNA + tilianin.