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. 2021 Sep 4;2021:6673967. doi: 10.1155/2021/6673967

Figure 6.

Figure 6

Tilianin restored long-term memory-related protein expression through p-CaMKII/ERK/CREB pathway in the hippocampus of rats with VaD. (a) Representative Western blot bands for p-CaMKII, total CaMKII, p-ERK1/2, total ERK1/2, p-CREB, and total CREB in the different groups. (b) Quantitative analysis of ratios of p-CaMKII/CaMKII, p-ERK/ERK, and p-CREB/CREB as observed in Western blots. (c) Representative Western blot bands of Bax and Bcl-2 in the different groups. (d) Quantitative analysis of the ratio of Bcl-2/Bax observed in Western blots and caspase-3 activity in the hippocampus. Results represent means ± SD, n = 5. ##P < 0.01, ###P < 0.001 vs. sham group; ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001 vs. 2VO group.