Figure 6.

Genetic interactions between the nuclear exosome with genes that are involved in the maintenance of cell homeostasis

(A and B) Comparisons of biological processes associated with genetic interactions of DIS3 identified in the genome-wide screen, extended RNA metabolism screen, and hits from genome-wide subset, excluding hits identified in the extended RNA metabolism screen. Bar plots represent the number of identified hits that were associated with biological processes according to the enrichment analysis using the DAVID direct GO database. The fill color of the bar plots represents Fisher’s exact p value. Enrichment analyses were performed separately for (A) synthetic lethal interactions and (B) suppressors.

(C) Functional connections of synthetic lethal interactors and suppressors of DIS3 that are associated with microtubules. The hits of enriched cellular compartment categories that were connected to microtubules were extracted from the enrichment results using the DAVID direct GO database and visualized in Cytoscape as a network in which edges represent association of genes (blue nodes for synthetic lethal interactions and yellow nodes for suppressors) with functional categories (pink nodes).

See also Figures S7–S9, and Tables S7 and S8.