Figure 9.

Plasma lipid levels and monocyte subsets in ApoE^−/−mice after bone marrow transplants. Lethally irradiated ApoE^−/− mice were transplanted with bone marrow cells from ApoE^−/− (EKO), APOE2, APOE3, and APOE4 mice and then fed a Western diet for 8 weeks. A, plasma cholesterol and (B) triglyceride levels were determined from N = 12 mice in each group. Blood cells from the APOE gene replacement mice were obtained for flow cytometry analysis of (C) total monocytes, (D) Ly6C^hi, and (E) Ly6C^lo monocytes. All data were evaluated by one-way ANOVA with the Student–Newman–Keuls post hoc test for statistical significance between groups as indicated. apoE, apolipoprotein E.