Table 2.
Hazard ratios (HR) with 95% confidence intervals (95%CI) for all-cause and cause-specific mortality associated with egg consumption in the Moli-sani Study cohort (n = 20,562)
| Egg consumption (n of eggs/week) | 1 Egg/week increment | ||||||
|---|---|---|---|---|---|---|---|
| > 0 ≤ 1 | > 1 ≤ 2 | > 2 ≤ 4 | > 4 | p for trend | HR (95%CI) | p Value | |
| N of subjects (%) | 5517 (26.8) | 7143 (34.8) | 6526 (31.7) | 1372 (6.7) | – | – | |
| All-cause mortality | |||||||
| N of deaths | 234 | 281 | 256 | 67 | – | – | – |
| Person-years | 44,712 | 58,776 | 54,630 | 11,914 | – | – | – |
| Event rates per 10,000 person-years | 52.3 | 47.8 | 46.9 | 56.2 | – | – | – |
| Model 1 | -1- | 1.13 (0.95–1.35) | 1.23 (1.03–1.48) | 1.55 (1.17–2.06) | 0.0018 | 1.07 (1.01–1.13) | 0.018 |
| Model 2 | -1- | 1.14 (0.96–1.37) | 1.21 (1.01–1.46) | 1.50 (1.13–1.99) | 0.0043 | 1.06 (1.00–1.12) | 0.037 |
| Model 3 | -1- | 1.14 (0.96–1.36) | 1.22 (1.01–1.46) | 1.50 (1.13–1.99) | 0.0044 | 1.06 (1.00–1.12) | 0.039 |
| CVD mortality | |||||||
| N of deaths | 71 | 90 | 87 | 23 | – | – | – |
| Event rates per 10,000 person-years | 15.9 | 15.3 | 15.9 | 19.3 | – | – | – |
| Model 1 | -1- | 1.23 (0.90–1.69) | 1.43 (1.03–1.97) | 1.80 (1.10–2.94) | 0.0076 | 1.11 (1.01–1.22) | 0.025 |
| Model 2 | -1- | 1.29 (0.94–1.77) | 1.43 (1.03–1.97) | 1.75 (1.07–2.88) | 0.011 | 1.10 (1.01–1.21) | 0.036 |
| Model 3 | -1- | 1.29 (0.94–1.77) | 1.43 (1.03–1.97) | 1.75 (1.07–2.87) | 0.010 | 1.10 (1.01–1.21) | 0.036 |
| IHD/ cerebrovascular mortality | |||||||
| N of deaths | 42 | 51 | 49 | 11 | – | – | – |
| Event rates per 10,000 person-years | 9.4 | 8.7 | 9.0 | 9.2 | – | – | – |
| Model 1 | -1- | 1.24 (0.82–1.87) | 1.47 (0.96–2.25) | 1.69 (0.85–3.38) | 0.046 | 1.13 (1.00–1.28) | 0.054 |
| Model 2 | -1- | 1.26 (0.83–1.90) | 1.44 (0.94–2.21) | 1.58 (0.79–3.17) | 0.072 | 1.11 (0.98–1.26) | 0.090 |
| Model 3 | -1- | 1.25 (0.83–1.90) | 1.44 (0.94–2.21) | 1.58 (0.79–3.17) | 0.072 | 1.11 (0.98–1.26) | 0.090 |
| Cancer mortality | |||||||
| N of deaths | 94 | 104 | 106 | 30 | – | – | – |
| Event rates per 10,000 person-years | 21.0 | 17.7 | 19.4 | 25.2 | – | – | – |
| Model 1 | -1- | 0.99 (0.75–1.32) | 1.19 (0.89–1.58) | 1.59 (1.04–2.45) | 0.039 | 1.06 (0.97–1.15) | 0.19 |
| Model 2 | -1- | 0.98 (0.74–1.31) | 1.16 (0.88–1.54) | 1.52 (0.99–2.33) | 0.070 | 1.05 (0.96–1.14) | 0.29 |
| Model 3 | -1- | 0.98 (0.74–1.30) | 1.16 (0.87–1.54) | 1.52 (0.99–2.33) | 0.070 | 1.05 (0.96–1.14) | 0.29 |
| Other causes mortality | |||||||
| N of deaths | 69 | 87 | 63 | 14 | – | – | – |
| Event rates per 10,000 person-years | 15.8 | 14.2 | 11.4 | 11.8 | – | – | – |
| Model 1 | -1- | 1.22 (0.89–1.68) | 1.07 (0.75–1.52) | 1.16 (0.64–2.11) | 0.66 | 1.02 (0.92–1.14) | 0.69 |
| Model 2 | -1- | 1.24 (0.90–1.71) | 1.07 (0.75–1.53) | 1.16 (0.64–2.11) | 0.68 | 1.02 (0.92–1.14) | 0.71 |
| Model 3 | -1- | 1.24 (0.90–1.71) | 1.07 (0.75–1.53) | 1.14 (0.63–2.08) | 0.68 | 1.02 (0.92–1.13) | 0.73 |
Model 1 adjusted for age (continuous), sex and energy intake (continuous)
Model 2 as in model 1 further adjusted for educational level (categorical), household income (categorical), residence (categorical), smoking (categorical), BMI (categorical), leisure-time PA (categorical), baseline diabetes (categorical), hypertension (categorical), hyperlipidaemia (categorical)
Model 3 as in model 2 further adjusted for the Mediterranean diet score (continuous)