Table 4.
Sub-group analysis for the association of 1 egg/week increment and all-cause and CVD mortality in the Moli-sani Study cohort (n = 20,562)
| All-cause mortality | CVD mortality | |||||
|---|---|---|---|---|---|---|
| N of deaths/n of subjects | HR (95%CI) | p for interaction | N of deaths | HR (95%CI) | p for interaction | |
| Whole sample | 838/20,562 | 1.06 (1.00–1.12) | – | 271 | 1.10 (1.01–1.20) | – |
| Aged < 65 years | 258/16,550 | 1.05 (0.95–1.16) | 0.37 | 58 | 1.08 (0.89–1.32) | 0.44 |
| Aged ≥ 65 years | 580/4012 | 1.09 (1.03–1.17) | 213 | 1.16 (1.05–1.28) | ||
| Women | 299/10,905 | 1.03 (0.94–1.14) | 0.19 | 104 | 1.19 (1.04–1.36) | 0.50 |
| Men | 539/9657 | 1.11 (1.04–1.18) | 167 | 1.11 (0.98–1.24) | ||
| Up to lower secondary education | 606/10,510 | 1.06 (1.00–1.13) | 0.88 | 205 | 1.11 (1.01–1.23) | 0.64 |
| Upper secondary/postsecondary | 232/10,052 | 1.05 (0.94–1.16) | 66 | 1.09 (0.88–1.34) | ||
| Non-smokers | 647/15,665 | 1.06 (1.00–1.13) | 0.89 | 212 | 1.09 (0.99–1.21) | 0.56 |
| Smokers | 191/4897 | 1.05 (0.94–1.17) | 59 | 1.07 (0.88–1.29) | ||
| Physical activity ≤ 30 min/d | 306/7402 | 1.07 (0.97–1.17) | 0.49 | 101 | 1.10 (0.94–1.28) | 0.81 |
| Physical activity > 30 min/d | 532/13,160 | 1.06 (0.99–1.13) | 170 | 1.11 (0.99–1.24) | ||
| Normal/overweight | 549/14,655 | 1.07 (1.00–1.14) | 0.81 | 165 | 1.12 (1.00–1.26) | 0.69 |
| Obese | 289/5907 | 1.07 (0.98–1.17) | 106 | 1.09 (0.94–1.26) | ||
| Free from diabetes | 701/19,501 | 1.06 (1.00–1.12) | 0.82 | 224 | 1.09 (0.99–1.20) | 0.20 |
| Subjects with diabetes | 113/820 | 1.09 (0.93–1.28) | 34 | 1.26 (0.95–1.65) | ||
| Free from hyperlipidaemia | 762/19,323 | 1.06 (1.00–1.12) | 0.97 | 250 | 1.07 (0.97–1.18) | 0.010 |
| Subjects with hyperlipidaemia | 66/1092 | 1.06 (0.86–1.32) | 18 | 1.66 (1.21–2.26) | ||
| Free from hypertension | 435/15,256 | 1.03 (0.96–1.11) | 0.35 | 107 | 1.00 (0.85–1.18) | 0.042 |
| Subjects with hypertension | 400/5175 | 1.08 (1.00–1.17) | 163 | 1.15 (1.03–1.28) | ||
| Excluding early deaths (follow up > 2 years) | 740/20,464 | 1.06 (1.00–1.12) | – | 233 | 1.14 (1.01–1.22) | – |
Hazard ratios with 95% CI from the multivariable model adjusted for sex, age (continuous), energy intake (continuous), educational level (categorical), household income (categorical), residence (categorical), smoking (categorical), BMI (categorical), leisure-time PA (categorical), baseline diabetes (categorical), hypertension (categorical), hyperlipidaemia (categorical), and the Mediterranean diet score (continuous)
Missing data: diabetes (n = 241), hypertension (n = 131) and hyperlipidaemia (n = 147)