Table 3.
Changes in lipoprotein size and particle concentration during fasting
| Parameter | All | |||
|---|---|---|---|---|
| 0 d | 7 d | 14 d | p value | |
| VLDL-s, nm | 47.57 ± 0.69 | 47.37 ± 0.34 | 47.63 ± 0.33 | 0.5181 |
| LDL-s, nm | 21.10 ± 0.07 | 21.11 ± 0.05 | 21.07 ± 0.05 | 0.1657 |
| HDL-s, nm | 9.07 ± 0.09a,b | 9.24 ± 0.08c | 9.39 ± 0.07 | < 0.0001 |
| Large VLDL-p, nmol/L | 4.74 ± 1.15a,b | 1.94 ± 1.08 | 1.90 ± 1.04 | < 0.0001 |
| LDL-p, nmol/L | 1479.3 ± 73.9b | 1477.7 ± 83.5c | 1186.2 ± 76.8 | < 0.0001 |
| Large LDL-p, nmol/L | 889.3 ± 53.1b | 823.0 ± 57.4c | 630.4 ± 54.2 | < 0.0001 |
| Small LDL-p, nmol/L | 590.0 ± 48.3 | 654.8 ± 42.0c | 555.2 ± 34.8 | 0.0001 |
| HDL-p, nmol/L | 36,241.0 ± 1156.5a,b | 30,920.9 ± 663.2c | 28,312.8 ± 613.1 | < 0.0001 |
| Large HDL-p, nmol/L | 6703.4 ± 699.1 | 6929.1 ± 666.9 | 7507.7 ± 561.8 | 0.0419 |
| Small HDL-p, nmol/L | 29,537.6 ± 1123.6a,b | 23,991.8 ± 758.1c | 20,792.8 ± 563.7 | < 0.0001 |
The overall p value is calculated by means of linear mixed models for repeated measures, with unstructured covariance structure to model within-subjects errors. Multiple comparison adjustment for heterogeneous variance between group was applied. Values are indicated as mean ± SEM.
Statistically significant differences between the three time points by means of adjusted p values are indicated with
a0 d (baseline) vs. 7 d
b0 d vs. 14 d
c7 d vs. 14 d.