Table 1.
Articles about optimizing dose and dosing time of ICG injection in laparoscopic fluorescence cholangiography
| Study | Year | Dose of ICG (mg) | Timing of injection | Bile duct-to-liver ratios (BLR)a |
|---|---|---|---|---|
| Verbeek et al. [21] | 2014 | 5, 10, 20 mg |
5 or 10 mg/30 min before incision; 10 or 20 mg/24 h prior to surgery |
1. BLR < 1, 5 mg or 10 mg/0.5 h 2. BLR = 2.3 (range 1.1–6.2), 10 mg/24 h 3. BLR = 1.7 (range 1.6–2.9), 20 mg/24 h |
| Zarrinpar et al. [22] | 2016 | 0.02, 0.04, 0.08, and 0.25 mg/kg | 10 ± 3 min, 45 ± 15 min, and 3 ± 1 h prior to surgery |
1. BLR < 1, 0.02, 0.04, 0.08, and 0.25 mg/kg 2. BLR < 1, 10 ± 3 min, 45 ± 15 min, and 3 ± 1 h |
| Boogerd et al. [16] | 2017 | 5 or 10 mg |
5 mg/0.5, 2, 4, or 6 h prior to surgery; 10 mg/4, 6, or 24 h prior to surgery |
1. BLR > 1, 5 mg/3 to 7 h 2. BLR > 1, 10 mg/5 to 25 hb |
| Tsutsui et al. [23] | 2018 | 25 mg | 0 h, 3 h, 6 h, 9 h, 12 h, 15 h, 18 h, 24 h prior to surgery | 1. BLR > 1, 25 mg/15, 18, and 24 h |
aBile duct-to-liver ratios (BLR), the ratio of fluorescence intensity between the bile duct and liver
bBLR > 1, 10 mg/5 to 25 h, Bile duct-to-liver ratios were greater than 1 after 10 mg ICG injection 5 to 25 h prior to surgery