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. 2002 Apr 22;2002(2):CD002158. doi: 10.1002/14651858.CD002158

Chapman 1997.

Methods Different doses used in devices. 
 Design: randomised, double‐blind, crossover study 
 Device: Turbuhaler 
 Drug: salbutamol 
 Dose: 200ug in TH; 100ug in pMDI, both treatments given qid for 2 weeks each. 
 Duration: 2 weeks
Participants 37 adults (18 women), mean age 39 yrs, FEV1 72% predicted, and 15% or greater increase in FEV1 after 200ug salbutamol from pMDI.
Interventions Total study duration was 4 weeks; 1 week run‐in followed by 2 weeks treatment and 1 week of washout in between.
Outcomes PEFR, FEV1 (measured 15 minutes post‐dose), preference, beta‐2 use and symptoms.
Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Unclear risk Information not available (Cochrane Grade B)