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. 2021 Aug 16;36(7):1817–1832. doi: 10.1007/s11011-021-00810-8

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© The Author(s) 2021

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Fig. 7 — Representative images of actin cytoskeleton staining in human astrocytes (HAs) cultured under normoglycaemic and hyperglycaemic (6–120 h) conditions in the absence or presence of therapeutic hypothermia. Treatment of normoglycaemic HAs with therapeutic hypothermia or exposure to hyperglycaemia markedly elevated actin stress fibre formation (indicated by white arrows) in a time-dependent manner. Therapeutic hypothermia significantly attenuated the impact of hyperglycaemia on stress fibre formation. Scale bars = 20 μm. NG: normoglycaemia. NG, normoglycaemia; NT, normothermia; HG, hyperglycaemia; TH, therapeutic hypothermia