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. 2021 Sep 13;11:18178. doi: 10.1038/s41598-021-97548-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Taxonomic representation of significant differences in relative abundances between the METH and Ctr groups. (a) Cladograms generated by LEfSe indicating differences in the bacterial taxa between the subjects with METH use disorder (METH) and the control (Ctr) subjects. Nodes in red indicate taxa that were enriched in the Ctr compared to the METH group, while nodes in green indicate taxa that were enriched in the Ctr compared to the METH group. (b) LDA scores for the bacterial taxa with differential abundances between the METH and Ctr groups. Positive and negative LDA scores indicate bacterial taxa enriched in the METH and Ctr groups, respectively. Only the taxa with p < 0.01 (Wilcoxon rank-sum test) and LDA > 4.0 are shown in the figure legend.