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. 2021 Sep 13;12(9):847. doi: 10.1038/s41419-021-04134-4

Fig. 2. Honokiol reduces mitochondrial acetylation and renal fibrosis.

Fig. 2

A, B: Amount of SIRT3 protein in kidney tissues from UUO mice injected with or without honokiol (HKL). α-tubulin served as the standard (*P < 0.05, †P < 0.05; n = 3). C, D Western blots of acetyl-lysine in tubular mitochondrial lysates from UUO mice injected with or without HKL on POD 1. SDHA served as the standard (*P < 0.05, †P < 0.05; n = 3). E, F Western blots of E-cadherin, Na/K-ATPase, AQP1, FN, and collagen I in UUO mice injected with or without HKL on POD 7. α-tubulin served as the standard (*P < 0.05, †P < 0.05; n = 3). G–J Representative images of H&E (G) (Star indicated tubular atrophy), Masson (H) (Arrow indicated collagen deposition), and immunohistochemical staining for FN (I) and collagen I (J) in kidneys on POD 7 after UUO in mice injected with honokiol. The bar indicates 50 μm.