Table 3.
Cytokine (pg/ml) values among groups and IgE (UI/ml) concentrations.
| Group | Cytokines | IgE concentration classification | p | ||
|---|---|---|---|---|---|
| Normal (< 25 UI/ml) |
Borderline (25–100 UI/ml) |
High (> 100 UI/ml) |
|||
| Control | IL-2 |
48.15 (35.00–58.48) |
56.45 (41.07–70.22) |
53.62 (3.82–102.20) |
0.651 |
| IL-4 |
32.69 (31.89–34.29) |
31.89 (29.48–32.69) |
30.28 (26.28–35.89) |
0.221 | |
| IL-17 |
515.73 (333.65–617.73) |
562.44 (386.08–688.28) |
584.37 (220.21–747.38) |
0.691 | |
| IL1-β |
4.51 (3.93–5.40) |
7.38 (2.51–16.21) |
8.19 (3.22–20.06) |
0.074 | |
| TGF-β |
496.35 (483.30–1,586.00) |
517.20 (491.90–706.80) |
493.60 (479.50–1,318.00) |
0.611 | |
| General cancer | IL-2 |
62.63 (0.74–203.69) |
48.11 (0.67–107.34) |
78.51 (0.49–1,025,523.40) |
0.329 |
| IL-4 |
27.80 (0.80–60.00) |
28.54 (6.40–57.60) |
21.60 (1.60–68.40) |
0.465 | |
| IL-17 |
376.07 (128.69–612.97) |
350.33 (171.59–688.28) |
404.19 (98.19–898.95) |
0.776 | |
| IL1-β |
5.55 (0.83–23.92) |
4.89 (2.71–12.40) |
5.20 (0.53–17.48) |
0.611 | |
| TGF-β |
952.55 (278.40–1,784.00) |
965.05 (485.20–1,672.00) |
1,111.50 (14.70–2,155.00) |
0.866 | |
|
Prostate Cancer |
IL-2 |
107.30 (1.08–133.62) |
48.25 (0.67–107.34) |
49.67 (0.49–79.97) |
0.242 |
| IL-4 |
5.20 (3.60–45.60) |
9.60 (6.40–30.00) |
25.80 (2.00–41.20) |
0.743 | |
| IL-17 |
543.38 (266.92–595.81) |
436.61 (190.66–600.57) |
478.55 (178.27–898.95) |
0.594 | |
| IL1-β |
5.45 (3.77–19.71) |
4.71 (3.77–12.40) |
3.27 (0.53–10.27) |
0.108 | |
| TGF-β |
1,241.00 (655.10–1,784.00) |
771.50 (490.60–1,275.00) |
1,370.00 (495.20–2,155.00) |
0.091 | |
| HNSCC | IL-2 |
68.65 (1.27–203.69) |
81.43 (70.84–92.01) |
96.57 (0.59–1,025,523.40) |
0.383 |
| IL-4 |
25.40 (0.80–39.20) |
56.80 (56.00–57.60) |
21.40 (1.60–68.40) |
0.123 | |
| IL-17 |
229.74 (157.29–612.97) |
216.87 (208.77–224.98) |
285.99 (98.19–636.80) |
0.891 | |
| IL1-β |
7.71 (3.83–23.92) |
4.61 (2.71–6.52) |
5.60 (2.56–17.48) |
0.404 | |
| TGF-β |
810.35 (278.40–1,241.00) |
565.85 (485.20–646.50) |
780.10 (486.60–1,939.00) |
0.409 | |
|
Stomach Cancer |
IL-2 |
55.51 (0.74–92.37) |
33.78 (0.69–79.24) |
96.02 (34.19–112.80) |
0.068 |
| IL-4 |
29.48 (6.00–60.00) |
31.49 (8.80–53.20) |
18.00 (2.40–28.68) |
0.152 | |
| IL-17 |
453.77 (128.69–553.86) |
418.49 (171.59–688.28) |
387.04 (196.38–605.34) |
0.655 | |
| IL1-β |
4.64 (0.83–11.84) |
4.89 (3.77–6.16) |
5.75 (2.66–8.80) |
0.560 | |
| TGF-β |
784.40 (500.00–1784.00) |
1,279.50 (663.70–1672.00) |
1,189.00 (14.70–1629.00) |
0.462 | |
Kruskal–Wallis Test. Values are presented as median (min–max).
Groups: Control (n = 20) and General Cancer (n = 60), that was the sum of three subgroups: Prostate (n = 20), HNSCC (n = 20), and Stomach (n = 20) Cancer.
Abbreviations: IgE = immunoglobulin E, IL = interleukin, TGF = transforming growth factor, HNSCC = head and neck squamous cell carcinoma.
Classification of IgE Levels based on Wiemels JL et al. 44.