Top panel, the mutational burden in each sample; right panel, the prevalence of mutations in each gene; bottom panel, from top to bottom, the source of the sample from the patients; pathological diagnosis of TAT sample from the respective patient (TAT unavailable in one case, labelled with grey); patients with or without relapse in follow-up; TNM stages of the patients. TAT tumour-adjacent tissue, pre-ctDNA pre-operative ctDNA, post-ctDNA post-operative ctDNA, pre-sctDNA pre-operative SctDNA, post-sctDNA post-operative SctDNA. Mutation types are labelled with different colours listed at the bottom left.