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. 2021 Jul 6;125(6):854–864. doi: 10.1038/s41416-021-01464-0

Fig. 5. Post-operative monitoring for disease relapse in (n = 27) HNSCC patients.

Fig. 5

a Disease-free survival according to the detection of TP53 mutation in adjacent mucosa sample. P value determined by log-rank test (n = 7 for TP53 mutation positive, n = 20 for TP53 mutation negative). b Mutation burdens in both post-surgical plasma and saliva fell sharply after resection compared with pre-surgery. P value determined by Wilcoxon’s rank-sum test. c Disease-free survival according to the detection of ctDNA in the post-operative plasma sample. P value determined by log-rank test (n = 6 for ctDNA positive, n = 21 for ctDNA negative). d Disease-free survival according to the detection of SctDNA in the post-operative saliva sample. P value determined by log-rank test (n = 7 for SctDNA positive, n = 20 for SctDNA negative).