Table 3.
Association of categorical measures of density with risk of interval, node-positive, and combined (interval or node-positive).
| Controls | Interval cancers | Node-positive cancers | Combined | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| # | % | # | % | OR | 95% CI | p-value | # | % | OR | 95% CI | p-value | # | % | OR | 95% CI | p-value | |
| FGV (cm3) | |||||||||||||||||
| 1st quartile | 137 | 22.6 | 26 | 8.8 | 1 | p < 0.01 | 17 | 7.1 | 1 | p < 0.01 | 34 | 8.2 | 1 | p < 0.01 | |||
| 2nd quartile | 114 | 18.8 | 56 | 18.9 | 2.6 | (1.5, 4.4) | 34 | 14.2 | 2.4 | (1.3, 4.6) | 66 | 16.0 | 2.3 | (1.4, 3.8) | |||
| 3rd quartile | 95 | 15.7 | 55 | 18.5 | 3 | (1.8, 5.3) | 31 | 13.0 | 2.6 | (1.4, 5.1) | 63 | 15.3 | 2.7 | (1.6, 4.4) | |||
| 4th quartile | 72 | 11.9 | 72 | 24.2 | 5.3 | (3.1, 9.1) | 42 | 17.6 | 4.7 | (2.5, 9.0) | 84 | 20.3 | 4.7 | (2.9, 7.8) | |||
| Missinga | 187 | 30.9 | 88 | 29.6 | 115 | 48.1 | 166 | 40.2 | |||||||||
| VBD (%) | |||||||||||||||||
| 1st quartile | 119 | 19.7 | 35 | 11.8 | 1 | p < 0.01 | 24 | 10.0 | 1 | p = 0.02 | 46 | 11.1 | 1 | p < 0.01 | |||
| 2nd quartile | 107 | 17.7 | 37 | 12.5 | 1.2 | (0.7, 2.0) | 27 | 11.3 | 1.2 | (0.7, 2.3) | 47 | 11.4 | 1.1 | (0.7, 1.8) | |||
| 3rd quartile | 101 | 16.7 | 65 | 21.9 | 2.1 | (1.3, 3.5) | 29 | 12.1 | 1.4 | (0.8, 2.6) | 73 | 17.7 | 1.8 | (1.1, 2.9) | |||
| 4th quartile | 91 | 15.0 | 72 | 24.2 | 2.7 | (1.6, 4.4) | 44 | 18.4 | 2.3 | (1.3, 4.2) | 81 | 19.6 | 2.3 | (1.4, 3.6) | |||
| Missinga | 187 | 30.9 | 88 | 29.6 | 115 | 48.1 | 166 | 40.2 | |||||||||
| VAS (%) | |||||||||||||||||
| 1st quartile | 174 | 28.8 | 53 | 17.8 | 1 | p < 0.01 | 55 | 23 | 1 | p = 0.14 | 86 | 20.8 | 1 | p < 0.01 | |||
| 2nd quartile | 157 | 25.9 | 59 | 19.9 | 1.2 | (0.8, 1.9) | 55 | 23 | 1.1 | (0.7, 1.7) | 89 | 21.6 | 1.1 | (0.8, 1.6) | |||
| 3rd quartile | 132 | 21.8 | 85 | 28.6 | 2.1 | (1.4, 3.2) | 63 | 26.4 | 1.5 | (1.0, 2.3) | 116 | 28.1 | 1.8 | (1.2, 2.5) | |||
| 4th quartile | 142 | 23.5 | 100 | 33.7 | 2.2 | (1.5, 3.4) | 66 | 27.6 | 1.5 | (1.0, 2.3) | 122 | 29.5 | 1.7 | (1.2, 2.4) | |||
| DG | |||||||||||||||||
| 1 | 27 | 4.5 | 5 | 1.7 | 1 | p < 0.01 | 4 | 1.7 | 1 | p = 0.01 | 6 | 1.5 | 1 | p < 0.01 | |||
| 2 | 206 | 34.0 | 70 | 23.6 | 1.7 | (0.7, 5.3) | 48 | 20.1 | 1.5 | (0.6, 5.4) | 91 | 22.0 | 1.9 | (0.8, 5.2) | |||
| 3 | 135 | 22.3 | 88 | 29.6 | 3.3 | (1.3, 10.1) | 44 | 18.4 | 2.1 | (0.8, 7.5) | 99 | 24.0 | 3.1 | (1.3, 8.6) | |||
| 4 | 50 | 8.3 | 46 | 15.5 | 4.7 | (1.8, 15.0) | 28 | 11.7 | 3.6 | (1.2, 13.1) | 51 | 12.3 | 4.4 | (1.7, 12.6) | |||
| Missinga | 187 | 30.9 | 88 | 29.6 | 115 | 48.1 | 166 | 40.2 | |||||||||
aMissing applies to all density measures except VAS.