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. 2021 Sep 13;11:18124. doi: 10.1038/s41598-021-97604-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Gel + Decorin promotes DRGN survival and neurite outgrowth in vitro in a serum-withdrawal model. (a) Gel + Decorin increased the proportion of surviving DRGN, which was similar to that observed with the positive control, fibroblast growth factor-2 (FGF2). Gel + Decorin treatment also increased (b) the mean DRGN neurite length and (c) the proportion of DRGN with neurites. (d) Representative photomicrographs to show neurite outgrowth after PBS, Gel + PBS, Gel + Decorin and FGF2 treatment. Scale bars in (d) = 100 µm. **P < 0.001; ***P < 0.0001, one-way ANOVA with Dunnett’s post hoc test. n = 3 wells/condition, 3 independent repeats, total n = 9 wells/condition.