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. 2021 Sep 13;11:18124. doi: 10.1038/s41598-021-97604-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Gel + Decorin promotes sparing of axons above and below the lesion site. NF200⁺ axons after (a) and (b) PBS treatment, (c) and (d) Gel + PBS treatment, (e) and (f) Gel + Decorin in T7 and T9 cord segments, respectively. Quantification of NF200⁺ axons at (g) T7 and (h) T9 to show significant axon sparing in Gel + Decorin versus Gel + PBS treatment above and below the lesion site. Gel + PBS treatment alone also promoted significant sparing below the lesion site at T7, when compared to PBS treatment alone (g). High power insets show more detail of the spared axons in the DC. Scale bars in (a)–(f) = 200 µm, insets to (a)–(f) = 100 µm. *P < 0.05; **P < 0.001, **P < 0.0001, one-way ANOVA with Dunnett’s post hoc test. n = 4 rats/group, 3 independent repeats, total n = 12 rats/group.