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. 2021 Sep 13;11:18124. doi: 10.1038/s41598-021-97604-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Gel + Decorin injections improved electrophysiological and functional recovery after DC injury. (a) Spike 2 processed CAP traces from representative Sham controls, PBS, Gel + PBS and Gel + Decorin-treated rats showing significant recovery of dorsum cord potentials in Gel + Decorin treated rats. There is also a slight improvement in Gel + PBS-treated animals. Dorsal hemisection between the stimulating and the recording electrodes at the end of the experiment ablated CAP traces in all animals demonstrating technical success of the experiment. (b) CAP amplitudes (mV) were attenuated in the Gel + PBS treated group but were significantly improved in Gel + Decorin injected rats. (c) Mean CAP area was significantly improved in Gel + Decorin versus Gel + PBS-treated rats. (d) Mean sensing time for the tape sensing and removal test and mean error ratios for the (e) horizontal ladder walking test both show significant recovery of sensory and locomotor function, respectively, after Gel + Decorin treatment. *P < 0.05, ***P < 0.0001, one-way ANOVA with Dunnett’s post hoc test; #P < 0.0012, linear mixed model (LMM); ##P < 0.0001, generalised linear mixed model (GLMM). n = 6 rats/group, 3 independent repeats, total n = 18 rats/group.