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. 2021 Sep 13;11:18156. doi: 10.1038/s41598-021-97433-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Plasma lipid metabolite differences between cases and controls in Fred Hutch (FH) and Roswell Park (RP) patient cohorts. Log₂ metabolite concentrations were regressed on case status with adjustment for age and BMI. (A) Volcano plots depicting estimated beta (β) coefficients and − log₁₀ P values for 546 individual lipid metabolites (left: FH, right: RP). Species satisfying FDR q < 0.05 are color-coded by lipid class, as indicated, with the remainder shown in light gray. Dashed horizontal line marks the Bonferroni-corrected threshold for statistical significance: − log₁₀ (0.05/546) = 4.04. (B) Lipid class assignments of species reaching q_Bonf < 0.05 (n = 23, top), or q_FDR < 0.05 (n = 249, bottom), in both cohorts.